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Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

BACKGROUND: The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refra...

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Detalles Bibliográficos
Autores principales:	Peres, Raphael S., Santos, Gabriela B., Cecilio, Nerry T., Jabor, Valquíria A. P., Niehues, Michael, Torres, Bruna G. S., Buqui, Gabriela, Silva, Carlos H. T. P., Costa, Teresa Dalla, Lopes, Norberto P., Nonato, Maria C., Ramalho, Fernando S., Louzada-Júnior, Paulo, Cunha, Thiago M., Cunha, Fernando Q., Emery, Flavio S., Alves-Filho, Jose C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341405/ https://www.ncbi.nlm.nih.gov/pubmed/28270195 http://dx.doi.org/10.1186/s13075-017-1236-x

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