Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives

The self-assembly of two derivatives of KLVFF, a fragment Aβ(16–20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1–42) is observed at sub-stoichiometric peptide concentrations. Fluorescence assays show that NH(2)-KLVFF-CONH(2) unde...

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Detalles Bibliográficos
Autores principales: Castelletto, V., Ryumin, P., Cramer, R., Hamley, I. W., Taylor, M., Allsop, D., Reza, M., Ruokolainen, J., Arnold, T., Hermida-Merino, D., Garcia, C. I., Leal, M. C., Castaño, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341572/
https://www.ncbi.nlm.nih.gov/pubmed/28272542
http://dx.doi.org/10.1038/srep43637

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