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Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy

PURPOSE: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroup...

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Autores principales: Bregman, Jana A., Herren, David J., Estopinal, Christopher B., Chocron, Isaac M., Harlow, Paula A., Warden, Cassandra, Brantley, Milam A., Samuels, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341621/
https://www.ncbi.nlm.nih.gov/pubmed/28245487
http://dx.doi.org/10.1167/iovs.16-20616
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author Bregman, Jana A.
Herren, David J.
Estopinal, Christopher B.
Chocron, Isaac M.
Harlow, Paula A.
Warden, Cassandra
Brantley, Milam A.
Samuels, David C.
author_facet Bregman, Jana A.
Herren, David J.
Estopinal, Christopher B.
Chocron, Isaac M.
Harlow, Paula A.
Warden, Cassandra
Brantley, Milam A.
Samuels, David C.
author_sort Bregman, Jana A.
collection PubMed
description PURPOSE: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. METHODS: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An additional 197 Caucasian patients with diabetes (98 with DR) were enrolled from the Vanderbilt Eye Institute (VEI). We tested for an association between European mitochondrial haplogroups and DR status. RESULTS: The percentage of diabetes patients with DR did not differ across the haplogroups (P = 0.32). The percentage of patients with nonproliferative DR (NPDR; P = 0.0084) and with PDR (P = 0.027) significantly differed across the haplogroups. In logistic regressions adjusting for sex, age, diabetes type, duration of diabetes, and hemoglobin A1c, neither haplogroup H nor haplogroup UK had a significant effect on DR compared with diabetic controls. Haplogroup UK was a significant risk factor (OR = 1.72 [1.13–2.59], P = 0.010) for NPDR compared with diabetic controls in the unadjusted analysis, but not in the adjusted analysis (OR = 1.29 [0.79–2.10], P = 0.20). CONCLUSIONS: Mitochondrial haplogroups H and UK were associated with severity, but not presence, of DR. These data argue that the effect of these haplogroups is related to ischemia and neovascularization, the defining features of PDR.
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spelling pubmed-53416212017-03-09 Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy Bregman, Jana A. Herren, David J. Estopinal, Christopher B. Chocron, Isaac M. Harlow, Paula A. Warden, Cassandra Brantley, Milam A. Samuels, David C. Invest Ophthalmol Vis Sci Genetics PURPOSE: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. METHODS: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An additional 197 Caucasian patients with diabetes (98 with DR) were enrolled from the Vanderbilt Eye Institute (VEI). We tested for an association between European mitochondrial haplogroups and DR status. RESULTS: The percentage of diabetes patients with DR did not differ across the haplogroups (P = 0.32). The percentage of patients with nonproliferative DR (NPDR; P = 0.0084) and with PDR (P = 0.027) significantly differed across the haplogroups. In logistic regressions adjusting for sex, age, diabetes type, duration of diabetes, and hemoglobin A1c, neither haplogroup H nor haplogroup UK had a significant effect on DR compared with diabetic controls. Haplogroup UK was a significant risk factor (OR = 1.72 [1.13–2.59], P = 0.010) for NPDR compared with diabetic controls in the unadjusted analysis, but not in the adjusted analysis (OR = 1.29 [0.79–2.10], P = 0.20). CONCLUSIONS: Mitochondrial haplogroups H and UK were associated with severity, but not presence, of DR. These data argue that the effect of these haplogroups is related to ischemia and neovascularization, the defining features of PDR. The Association for Research in Vision and Ophthalmology 2017-02 /pmc/articles/PMC5341621/ /pubmed/28245487 http://dx.doi.org/10.1167/iovs.16-20616 Text en Copyright 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Genetics
Bregman, Jana A.
Herren, David J.
Estopinal, Christopher B.
Chocron, Isaac M.
Harlow, Paula A.
Warden, Cassandra
Brantley, Milam A.
Samuels, David C.
Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title_full Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title_fullStr Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title_full_unstemmed Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title_short Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy
title_sort mitochondrial haplogroups affect severity but not prevalence of diabetic retinopathy
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341621/
https://www.ncbi.nlm.nih.gov/pubmed/28245487
http://dx.doi.org/10.1167/iovs.16-20616
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