Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

MARCH5, an OMM-associated E3 ubiquitin ligase, controls mitochondrial function. Despite its importance, the mechanism and factors controlling MARCH5 activity are largely unknown. Here we report that the MARCH5 C-terminal domain plays a critical role in degradation of MARCH5 substrates, likely by fac...

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Detalles Bibliográficos
Autores principales: Cherok, Edward, Xu, Shan, Li, Sunan, Das, Shweta, Meltzer, W. Alex, Zalzman, Michal, Wang, Chunxin, Karbowski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341724/
https://www.ncbi.nlm.nih.gov/pubmed/27932492
http://dx.doi.org/10.1091/mbc.E16-04-0208

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