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Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells

In prior work we reported that advanced stage, drug-resistant pancreatic cancer cells (the SW1990 line) can be sensitized to the EGFR-targeting tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib by treatment with 1,3,4-O-Bu(3)ManNAc (Bioorg. Med. Chem. Lett. (2015) 25(6):1223-7). Here we prov...

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Detalles Bibliográficos
Autores principales:	Mathew, Mohit P., Tan, Elaine, Saeui, Christopher T., Bovonratwet, Patawut, Sklar, Samuel, Bhattacharya, Rahul, Yarema, Kevin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341816/ https://www.ncbi.nlm.nih.gov/pubmed/27613843 http://dx.doi.org/10.18632/oncotarget.11582

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