Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer

Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show i...

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Detalles Bibliográficos
Autores principales: Trott, Josephine F., Kim, Jeffrey, Aboud, Omran Abu, Wettersten, Hiromi, Stewart, Benjamin, Berryhill, Grace, Uzal, Francisco, Hovey, Russell C., Chen, Ching-Hsien, Anderson, Katie, Graef, Ashley, Sarver, Aaron L, Modiano, Jaime F., Weiss, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341819/
https://www.ncbi.nlm.nih.gov/pubmed/27572319
http://dx.doi.org/10.18632/oncotarget.11658

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