Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

Most cancer DNA sequencing studies have prioritized recurrent non-synonymous coding mutations in order to identify novel cancer-related mutations. Although attention is increasingly being paid to mutations in non-coding regions, standard approaches to identifying significant mutations may not be app...

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Detalles Bibliográficos
Autores principales: Colebatch, Andrew J., Di Stefano, Leon, Wong, Stephen Q., Hannan, Ross D., Waring, Paul M., Dobrovic, Alexander, McArthur, Grant A., Papenfuss, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341821/
https://www.ncbi.nlm.nih.gov/pubmed/27611953
http://dx.doi.org/10.18632/oncotarget.11892

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