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New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals

Prostatitis is a common disease contributing to 8% of all urologist visits. Yet the etiology and effective treatment remain to be further elucidated. Using a non-obese diabetes mouse model that can be induced by autoimmune response for the spontaneous development of prostatitis, we found that inject...

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Autores principales: Lin, Shin-Jen, Chou, Fu-Ju, Lin, Chang-Yi, Chang, Hong-Chiang, Yeh, Shuyuan, Chang, Chawnshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341836/
https://www.ncbi.nlm.nih.gov/pubmed/27564257
http://dx.doi.org/10.18632/oncotarget.11484
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author Lin, Shin-Jen
Chou, Fu-Ju
Lin, Chang-Yi
Chang, Hong-Chiang
Yeh, Shuyuan
Chang, Chawnshang
author_facet Lin, Shin-Jen
Chou, Fu-Ju
Lin, Chang-Yi
Chang, Hong-Chiang
Yeh, Shuyuan
Chang, Chawnshang
author_sort Lin, Shin-Jen
collection PubMed
description Prostatitis is a common disease contributing to 8% of all urologist visits. Yet the etiology and effective treatment remain to be further elucidated. Using a non-obese diabetes mouse model that can be induced by autoimmune response for the spontaneous development of prostatitis, we found that injection of the ASC-J9(®) at 75 mg/Kg body weight/48 hours led to significantly suppressed prostatitis that was accompanied with reduction of lymphocyte infiltration with reduced CD4(+) T cells in prostate. In vitro studies with a co-culture system also confirmed that ASC-J9(®) treatment could suppress the CD4(+) T cell migration to prostate stromal cells. Mechanisms dissection indicated that ASC-J9(®) can suppress CD4(+) T cell migration via decreasing the cytokine CCL2 in vitro and in vivo, and restoring CCL2 could interrupt the ASC-J9(®) suppressed CD4(+) T cell migration. Together, results from in vivo and in vitro studies suggest that ASC-J9(®) can suppress prostatitis by altering the autoimmune response induced by CD4(+) T cell recruitment, and using ASC-J9(®) may help us to develop a potential new therapy to battle the prostatitis with little side effects.
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spelling pubmed-53418362017-03-23 New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals Lin, Shin-Jen Chou, Fu-Ju Lin, Chang-Yi Chang, Hong-Chiang Yeh, Shuyuan Chang, Chawnshang Oncotarget Research Paper Prostatitis is a common disease contributing to 8% of all urologist visits. Yet the etiology and effective treatment remain to be further elucidated. Using a non-obese diabetes mouse model that can be induced by autoimmune response for the spontaneous development of prostatitis, we found that injection of the ASC-J9(®) at 75 mg/Kg body weight/48 hours led to significantly suppressed prostatitis that was accompanied with reduction of lymphocyte infiltration with reduced CD4(+) T cells in prostate. In vitro studies with a co-culture system also confirmed that ASC-J9(®) treatment could suppress the CD4(+) T cell migration to prostate stromal cells. Mechanisms dissection indicated that ASC-J9(®) can suppress CD4(+) T cell migration via decreasing the cytokine CCL2 in vitro and in vivo, and restoring CCL2 could interrupt the ASC-J9(®) suppressed CD4(+) T cell migration. Together, results from in vivo and in vitro studies suggest that ASC-J9(®) can suppress prostatitis by altering the autoimmune response induced by CD4(+) T cell recruitment, and using ASC-J9(®) may help us to develop a potential new therapy to battle the prostatitis with little side effects. Impact Journals LLC 2016-08-22 /pmc/articles/PMC5341836/ /pubmed/27564257 http://dx.doi.org/10.18632/oncotarget.11484 Text en Copyright: © 2016 Lin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lin, Shin-Jen
Chou, Fu-Ju
Lin, Chang-Yi
Chang, Hong-Chiang
Yeh, Shuyuan
Chang, Chawnshang
New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title_full New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title_fullStr New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title_full_unstemmed New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title_short New therapy with ASC-J9(®) to suppress the prostatitis via altering the cytokine CCL2 signals
title_sort new therapy with asc-j9(®) to suppress the prostatitis via altering the cytokine ccl2 signals
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341836/
https://www.ncbi.nlm.nih.gov/pubmed/27564257
http://dx.doi.org/10.18632/oncotarget.11484
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