Cargando…

Pesticide exposure and risk of bladder cancer: A meta-analysis

OBJECTIVE: We conducted a meta-analysis to quantitatively evaluate the correlation between pesticide exposure and the risk of bladder cancer by summarizing the results of published case-control and cohort studies. METHODS: A systematic literature search of articles update to February 2015 was conduc...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Zhen, Wang, Xiao, Xie, Bo, Zhu, Yi, Wu, Jian, Li, Shiqi, Meng, Shuai, Zheng, Xiangyi, Ji, Alin, Xie, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341850/
https://www.ncbi.nlm.nih.gov/pubmed/27557494
http://dx.doi.org/10.18632/oncotarget.11397
_version_ 1782513046386638848
author Liang, Zhen
Wang, Xiao
Xie, Bo
Zhu, Yi
Wu, Jian
Li, Shiqi
Meng, Shuai
Zheng, Xiangyi
Ji, Alin
Xie, Liping
author_facet Liang, Zhen
Wang, Xiao
Xie, Bo
Zhu, Yi
Wu, Jian
Li, Shiqi
Meng, Shuai
Zheng, Xiangyi
Ji, Alin
Xie, Liping
author_sort Liang, Zhen
collection PubMed
description OBJECTIVE: We conducted a meta-analysis to quantitatively evaluate the correlation between pesticide exposure and the risk of bladder cancer by summarizing the results of published case-control and cohort studies. METHODS: A systematic literature search of articles update to February 2015 was conducted via Pubmed, Web of Science, Cochrane Library, and the Chinese National Knowledge Infrastructure (CNKI) databases, and the references of the retrieved articles. Fixed- or random-effect models were used to summarize the estimates of OR with 95% CIs for the highest versus the lowest exposure of pesticide. RESULTS: The pooled OR estimates indicated that pesticide exposure was associated with an increased risk of bladder cancer (OR=1.649, 95% CI 1.223-2.223). In subgroup analysis, we detected pesticide exposure demonstrated as a significant risk factor on bladder cancer in America (OR=1.741, 95% CI 1.270-2.388). Similar results were discovered in both case-control group and cohort group (OR=2.075, 95% CI 1.183-3.638, OR=1.146, 95% CI 1.074-1.223, respectively). No evidence of publication bias was found by Begg's or Egger's test (P = 0.210, P = 0.358, respectively). CONCLUSION: In conclusion, our meta-analysis indicated that pesticide exposure was associated with an increased risk of bladder cancer. Further researches should be conducted to confirm the findings in our study and better clarify the potential biological mechanisms.
format Online
Article
Text
id pubmed-5341850
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-53418502017-03-23 Pesticide exposure and risk of bladder cancer: A meta-analysis Liang, Zhen Wang, Xiao Xie, Bo Zhu, Yi Wu, Jian Li, Shiqi Meng, Shuai Zheng, Xiangyi Ji, Alin Xie, Liping Oncotarget Research Paper OBJECTIVE: We conducted a meta-analysis to quantitatively evaluate the correlation between pesticide exposure and the risk of bladder cancer by summarizing the results of published case-control and cohort studies. METHODS: A systematic literature search of articles update to February 2015 was conducted via Pubmed, Web of Science, Cochrane Library, and the Chinese National Knowledge Infrastructure (CNKI) databases, and the references of the retrieved articles. Fixed- or random-effect models were used to summarize the estimates of OR with 95% CIs for the highest versus the lowest exposure of pesticide. RESULTS: The pooled OR estimates indicated that pesticide exposure was associated with an increased risk of bladder cancer (OR=1.649, 95% CI 1.223-2.223). In subgroup analysis, we detected pesticide exposure demonstrated as a significant risk factor on bladder cancer in America (OR=1.741, 95% CI 1.270-2.388). Similar results were discovered in both case-control group and cohort group (OR=2.075, 95% CI 1.183-3.638, OR=1.146, 95% CI 1.074-1.223, respectively). No evidence of publication bias was found by Begg's or Egger's test (P = 0.210, P = 0.358, respectively). CONCLUSION: In conclusion, our meta-analysis indicated that pesticide exposure was associated with an increased risk of bladder cancer. Further researches should be conducted to confirm the findings in our study and better clarify the potential biological mechanisms. Impact Journals LLC 2016-08-19 /pmc/articles/PMC5341850/ /pubmed/27557494 http://dx.doi.org/10.18632/oncotarget.11397 Text en Copyright: © 2016 Liang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liang, Zhen
Wang, Xiao
Xie, Bo
Zhu, Yi
Wu, Jian
Li, Shiqi
Meng, Shuai
Zheng, Xiangyi
Ji, Alin
Xie, Liping
Pesticide exposure and risk of bladder cancer: A meta-analysis
title Pesticide exposure and risk of bladder cancer: A meta-analysis
title_full Pesticide exposure and risk of bladder cancer: A meta-analysis
title_fullStr Pesticide exposure and risk of bladder cancer: A meta-analysis
title_full_unstemmed Pesticide exposure and risk of bladder cancer: A meta-analysis
title_short Pesticide exposure and risk of bladder cancer: A meta-analysis
title_sort pesticide exposure and risk of bladder cancer: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341850/
https://www.ncbi.nlm.nih.gov/pubmed/27557494
http://dx.doi.org/10.18632/oncotarget.11397
work_keys_str_mv AT liangzhen pesticideexposureandriskofbladdercancerametaanalysis
AT wangxiao pesticideexposureandriskofbladdercancerametaanalysis
AT xiebo pesticideexposureandriskofbladdercancerametaanalysis
AT zhuyi pesticideexposureandriskofbladdercancerametaanalysis
AT wujian pesticideexposureandriskofbladdercancerametaanalysis
AT lishiqi pesticideexposureandriskofbladdercancerametaanalysis
AT mengshuai pesticideexposureandriskofbladdercancerametaanalysis
AT zhengxiangyi pesticideexposureandriskofbladdercancerametaanalysis
AT jialin pesticideexposureandriskofbladdercancerametaanalysis
AT xieliping pesticideexposureandriskofbladdercancerametaanalysis