An anti-ErbB2 fully human antibody circumvents trastuzumab resistance

Trastuzumab, an anti-HER2/ErbB2 humanized antibody, has shown great clinical benefits in ErbB2-positive breast cancer treatment. Despite of its effectiveness, response rate to trastuzumab is limited and resistance is common. Here, we developed a new anti-ErbB2 antibody, denoted as H2-18, which was i...

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Detalles Bibliográficos
Autores principales: Lu, Qiong, Wang, Lingfei, Zhang, Yajun, Yu, Xiaojie, Wang, Chao, Wang, Huajing, Yang, Yang, Chong, Xiaodan, Xia, Tian, Meng, Yanchun, Wang, Yuxiao, Lu, Cuihua, Zhou, Lijun, Li, Bohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341862/
https://www.ncbi.nlm.nih.gov/pubmed/27564098
http://dx.doi.org/10.18632/oncotarget.11562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341862/
https://www.ncbi.nlm.nih.gov/pubmed/27564098
http://dx.doi.org/10.18632/oncotarget.11562

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