Cargando…

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence

Glioblastoma multiforme (GBM), a malignant brain tumor with a dismal prognosis, shows a high level of chemo- and radioresistance and, therefore, attempts to sensitize glioma cells are highly desired. Here, we addressed the question of whether artesunate (ART), a drug currently used in the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berte, Nancy, Lokan, Stefanie, Eich, Marcus, Kim, Ella, Kaina, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341871/ https://www.ncbi.nlm.nih.gov/pubmed/27626497 http://dx.doi.org/10.18632/oncotarget.11972

Ejemplares similares

Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair
por: Christmann, Markus, et al.
Publicado: (2016)

Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics
por: Beltzig, Lea, et al.
Publicado: (2022)

Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence
por: Wei, Shupei, et al.
Publicado: (2019)

Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69
por: Kaina, Bernd
Publicado: (2019)

SPDR-01 INHIBITION OF HOMOLOGOUS RECOMBINATION, PARP INHIBITOR, OR DIANHYDROGALACTITOL OVERCOMES TEMOZOLOMIDE-RESISTANCE IN GLIOMA CELLS
por: Ohba, Shigeo, et al.
Publicado: (2019)

Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage
por: Knizhnik, Anna V., et al.
Publicado: (2013)

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells
por: Beltzig, Lea, et al.
Publicado: (2022)

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM
por: Tomicic, Maja T., et al.
Publicado: (2015)

Accumulation of Temozolomide-Induced Apoptosis, Senescence and DNA Damage by Metronomic Dose Schedule: A Proof-of-Principle Study with Glioblastoma Cells
por: Beltzig, Lea, et al.
Publicado: (2021)

Temozolomide – Just a Radiosensitizer?
por: Kaina, Bernd, et al.
Publicado: (2022)

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2
por: Zhang, Xin, et al.
Publicado: (2022)

Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
por: He, Yang, et al.
Publicado: (2019)

Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination
por: Reich, Thomas R., et al.
Publicado: (2021)

Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids
por: Günther, W, et al.
Publicado: (2003)

Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas
por: Ulasov, Ilya, et al.
Publicado: (2013)

ZSTK474 Sensitizes Glioblastoma to Temozolomide by Blocking Homologous Recombination Repair
por: Jiao, Wenhui, et al.
Publicado: (2022)

Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment
por: Schwarzenbach, Christian, et al.
Publicado: (2021)

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells
por: Kaina, Bernd, et al.
Publicado: (2020)

ATR inhibition reverses the resistance of homologous recombination deficient MGMT(low)/MMR(proficient) cancer cells to temozolomide
por: El Touny, Lara H., et al.
Publicado: (2021)

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells
por: Filippi-Chiela, Eduardo C, et al.
Publicado: (2013)

Inhibition of DNA Repair in Combination with Temozolomide or Dianhydrogalactiol Overcomes Temozolomide-Resistant Glioma Cells
por: Ohba, Shigeo, et al.
Publicado: (2021)

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma
por: Yuan, Qiuyun, et al.
Publicado: (2021)

Temozolomide in malignant glioma
por: Dresemann, Gregor
Publicado: (2010)

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities
por: Daniel, Paul, et al.
Publicado: (2019)

Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy
por: Huang, Zhiying, et al.
Publicado: (2022)

Human Monocytes Undergo Excessive Apoptosis following Temozolomide Activating the ATM/ATR Pathway While Dendritic Cells and Macrophages Are Resistant
por: Bauer, Martina, et al.
Publicado: (2012)

Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe
por: Pérès, Elodie A., et al.
Publicado: (2014)

Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
por: Kanzawa, T, et al.
Publicado: (2003)

Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2
por: Zhang, Xin, et al.
Publicado: (2018)

Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
por: Ghadaouia, Sabrina, et al.
Publicado: (2021)

Recent Advances in the Therapeutic Efficacy of Artesunate
por: Ruwizhi, Ngonidzashe, et al.
Publicado: (2022)

Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses
por: Stratenwerth, Björn, et al.
Publicado: (2021)

Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
por: Yu, Zhiyun, et al.
Publicado: (2015)

Temozolomide induces senescence but not apoptosis in human melanoma cells
por: Mhaidat, N M, et al.
Publicado: (2007)

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
por: D'Alessandro, Giuseppina, et al.
Publicado: (2016)

PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas
por: Koncar, Robert F., et al.
Publicado: (2017)

Apcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide
por: Ding, Yiming, et al.
Publicado: (2021)

HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines
por: Kim, Jin Wook, et al.
Publicado: (2014)

Temozolomide Chemotherapy in Patients with Recurrent Malignant Gliomas
por: Yang, Seung-Ho, et al.
Publicado: (2006)

The strategy for enhancing temozolomide against malignant glioma
por: Nakada, Mitsutoshi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hi4nb7i87uk6hdm9fg7ot3hmpg