Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM1...

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Detalles Bibliográficos
Autores principales: Ren, Hui, Guo, Hua, Thakur, Asmitananda, Zhang, Shuo, Wang, Ting, Liang, Yiqian, Shi, Puyu, Gao, Lei, Liu, Feng, Feng, Jing, Chen, Tianjun, Yang, Tian, Shang, Dong, Liu, Johnson J., Xu, Feng, Chen, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://www.ncbi.nlm.nih.gov/pubmed/27572309
http://dx.doi.org/10.18632/oncotarget.11645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://www.ncbi.nlm.nih.gov/pubmed/27572309
http://dx.doi.org/10.18632/oncotarget.11645

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