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Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer

Connexin 43, a gap junction protein, coordinates cell-to-cell communication and adhesion. Altered Connexin 43 expression associated with cancer development and progression. In this study, we assessed Connexin 43 expression for association with clinicopathological features and biochemical recurrence...

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Autores principales: Xu, Ning, Chen, Hui-Jun, Chen, Shao-Hao, Xue, Xue-Yi, Chen, Hong, Zheng, Qing-Shui, Wei, Yong, Li, Xiao-Dong, Huang, Jin-Bei, Cai, Hai, Sun, Xiong-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341890/
https://www.ncbi.nlm.nih.gov/pubmed/27623212
http://dx.doi.org/10.18632/oncotarget.11231
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author Xu, Ning
Chen, Hui-Jun
Chen, Shao-Hao
Xue, Xue-Yi
Chen, Hong
Zheng, Qing-Shui
Wei, Yong
Li, Xiao-Dong
Huang, Jin-Bei
Cai, Hai
Sun, Xiong-Lin
author_facet Xu, Ning
Chen, Hui-Jun
Chen, Shao-Hao
Xue, Xue-Yi
Chen, Hong
Zheng, Qing-Shui
Wei, Yong
Li, Xiao-Dong
Huang, Jin-Bei
Cai, Hai
Sun, Xiong-Lin
author_sort Xu, Ning
collection PubMed
description Connexin 43, a gap junction protein, coordinates cell-to-cell communication and adhesion. Altered Connexin 43 expression associated with cancer development and progression. In this study, we assessed Connexin 43 expression for association with clinicopathological features and biochemical recurrence of prostate cancer after radical prostatectomy. Pathological specimens were collected from 243 patients who underwent radical prostatectomy and from 60 benign prostatic hyperplasia (BPH) patients to construct tissue microarrays and immunohistochemical analysis of Connexin 43 expression. Kaplan-Meier curves and multivariable Cox proportion hazard model were performed to associate Connexin 43 expression with postoperative biochemical recurrence-free survival (BFS). Connexin 43 expression was significantly reduced or lost in tumor tissues compared to that of BPHs (39.1% vs. 96.7%, P<0.001). Reduced Connexin 43 expression was associated with high levels of preoperative PSA, high Gleason score, advanced pT stage, positive surgical margin, extracapsular extension, and seminal vesicle invasion (P < 0.05, for all). Kaplan–Meier curves showed that reduced Connexin 43 expression was associated with shortened postoperative BFS (P < 0.001). Multivariate analysis showed that reduced Connexin 43 expression, high Gleason score and advanced pT stage were independent predictors for BFS of patients (P < 0.05). Connexin 43 expression was significantly reduced or lost in prostate cancer tissues, which was associated with advanced clinicopathological features and poor BFS of patients after radical prostatectomy.
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spelling pubmed-53418902017-03-23 Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer Xu, Ning Chen, Hui-Jun Chen, Shao-Hao Xue, Xue-Yi Chen, Hong Zheng, Qing-Shui Wei, Yong Li, Xiao-Dong Huang, Jin-Bei Cai, Hai Sun, Xiong-Lin Oncotarget Clinical Research Paper Connexin 43, a gap junction protein, coordinates cell-to-cell communication and adhesion. Altered Connexin 43 expression associated with cancer development and progression. In this study, we assessed Connexin 43 expression for association with clinicopathological features and biochemical recurrence of prostate cancer after radical prostatectomy. Pathological specimens were collected from 243 patients who underwent radical prostatectomy and from 60 benign prostatic hyperplasia (BPH) patients to construct tissue microarrays and immunohistochemical analysis of Connexin 43 expression. Kaplan-Meier curves and multivariable Cox proportion hazard model were performed to associate Connexin 43 expression with postoperative biochemical recurrence-free survival (BFS). Connexin 43 expression was significantly reduced or lost in tumor tissues compared to that of BPHs (39.1% vs. 96.7%, P<0.001). Reduced Connexin 43 expression was associated with high levels of preoperative PSA, high Gleason score, advanced pT stage, positive surgical margin, extracapsular extension, and seminal vesicle invasion (P < 0.05, for all). Kaplan–Meier curves showed that reduced Connexin 43 expression was associated with shortened postoperative BFS (P < 0.001). Multivariate analysis showed that reduced Connexin 43 expression, high Gleason score and advanced pT stage were independent predictors for BFS of patients (P < 0.05). Connexin 43 expression was significantly reduced or lost in prostate cancer tissues, which was associated with advanced clinicopathological features and poor BFS of patients after radical prostatectomy. Impact Journals LLC 2016-08-11 /pmc/articles/PMC5341890/ /pubmed/27623212 http://dx.doi.org/10.18632/oncotarget.11231 Text en Copyright: © 2016 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Xu, Ning
Chen, Hui-Jun
Chen, Shao-Hao
Xue, Xue-Yi
Chen, Hong
Zheng, Qing-Shui
Wei, Yong
Li, Xiao-Dong
Huang, Jin-Bei
Cai, Hai
Sun, Xiong-Lin
Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title_full Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title_fullStr Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title_full_unstemmed Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title_short Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
title_sort reduced connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341890/
https://www.ncbi.nlm.nih.gov/pubmed/27623212
http://dx.doi.org/10.18632/oncotarget.11231
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