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A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

Doxorubicin, an anthracycline antibiotic, is a commonly used anticancer drug. In spite of its widespread usage, its therapeutic effect is limited by its cardiotoxicity. On the cellular level, Doxorubicin-induced cardiotoxicity manifests as stress induced premature senescence. Previously, we demonstr...

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Detalles Bibliográficos
Autores principales:	Ghosh, Asish K., Rai, Rahul, Park, Kitae E., Eren, Mesut, Miyata, Toshio, Wilsbacher, Lisa D., Vaughan, Douglas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341920/ https://www.ncbi.nlm.nih.gov/pubmed/27736799 http://dx.doi.org/10.18632/oncotarget.12494

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