LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors

Liver kinase B1 (LKB1) functions as a tumor suppressor encoded by STK11, a gene that mutated in Peutz-Jeghers syndrome and in sporadic cancers. Previous studies showed that LKB1 participates in IR- and ROS-induced DNA damage response (DDR). However, the impact of LKB1 mutations on targeted cancer th...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Shu, Chen, Jianfeng, Cui, Fengmei, Wang, Huibo, Wang, Shuai, Hang, Wei, Zeng, Qinghua, Quan, Cheng-Shi, Zhai, Ying-Xian, Wang, Jian-Wei, Shen, Xiang-Feng, Jian, Yong-Ping, Zhao, Rui-Xun, Werle, Kaitlin D., Cui, Rutao, Liang, Jiyong, Li, Yu-Lin, Xu, Zhi-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341986/
https://www.ncbi.nlm.nih.gov/pubmed/27705915
http://dx.doi.org/10.18632/oncotarget.12334

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