Cargando…

Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases

The detailed molecular mechanisms and safety issues of recombinant human bone morphogenetic protein-2 (rhBMP-2) usage in bone graft substitution remain poorly understood. To investigate the molecular mechanisms underlying the function of rhBMP-2 in gastric cancer cells, we used microarrays to determ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Kwang Bok, Jin, Hua, Ye, Shuai, Park, Byung Hyun, Kim, Soo Mi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341992/ https://www.ncbi.nlm.nih.gov/pubmed/27636990 http://dx.doi.org/10.18632/oncotarget.11969

Ejemplares similares

Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex
por: Altiner, Pinar, et al.
Publicado: (2023)

Expression of aurora kinase A correlates with the Wnt‐modulator RACGAP1 in gastric cancer
por: Bornschein, Jan, et al.
Publicado: (2016)

Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits
por: Kim, Chul-Hun, et al.
Publicado: (2017)

Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma
por: Diaz, Roberto Jose, et al.
Publicado: (2014)

Aurora kinase A is a possible target of OSU-03012 to destabilize MYC family proteins
por: SILVA, ANDRES, et al.
Publicado: (2014)

Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins
por: Chi, Ya-Hui, et al.
Publicado: (2021)

OTHR-02. CHIMERIC AURORA A KINASE (AURKA) DEGRADERS EFFICIENTLY TARGET N-MYC
por: Valinciute, Gintvile, et al.
Publicado: (2023)

Effect of Bone Morphogenetic Protein-2 on Proliferation and Apoptosis of Gastric Cancer Cells
por: Zhang, Junjie, et al.
Publicado: (2012)

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review
por: Gavriilidis, Paschalis, et al.
Publicado: (2015)

Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases
por: Liu, Wang, et al.
Publicado: (2016)

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer
por: Jacobsen, Annika, et al.
Publicado: (2018)

Aurora kinases in ovarian cancer
por: Pérez-Fidalgo, J Alejandro, et al.
Publicado: (2020)

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
por: Hochegger, Helfrid, et al.
Publicado: (2013)

The Aurora kinase A Regulates GSK-3β in Gastric Cancer Cells
por: Dar, Altaf A, et al.
Publicado: (2008)

Effect of recombinant human bone morphogenetic protein-2 on bisphosphonate-treated osteoblasts
por: Kwon, Taek-Kyun, et al.
Publicado: (2014)

Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
por: Okubo, Yasunori, et al.
Publicado: (2007)

Recombinant human bone morphogenetic protein-2 in the treatment of bone fractures
por: Ghodadra, Neil, et al.
Publicado: (2008)

Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target
por: Hartsink-Segers, S A, et al.
Publicado: (2013)

Inactivation of the Akt/FOXM1 Signaling Pathway by Panobinostat Suppresses the Proliferation and Metastasis of Gastric Cancer Cells
por: Lee, Na-Ri, et al.
Publicado: (2021)

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
por: Hao, Yi-Heng, et al.
Publicado: (2019)

ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration
por: Vo, Tam Thuy Lu, et al.
Publicado: (2017)

An Aurora Kinase B–Based Mouse System to Efficiently Identify and Analyze Proliferating Cardiomyocytes
por: Fu, Wenbin, et al.
Publicado: (2020)

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc
por: Boi, Dalila, et al.
Publicado: (2021)

The Aurora Kinases in Cell Cycle and Leukemia
por: Goldenson, Benjamin, et al.
Publicado: (2014)

Ubiquitin-Mediated Degradation of Aurora Kinases
por: Lindon, Catherine, et al.
Publicado: (2016)

Effect of bone morphogenetic protein-2/hydroxyapatite on ankle fusion with bone defect in a rabbit model: a pilot study
por: Dang, Le Hoang Nam, et al.
Publicado: (2020)

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins
por: Carmena, Mar, et al.
Publicado: (2009)

The concern on clinical use of recombinant human bone morphogenetic protein-2
por: Wiwanitkit, Viroj
Publicado: (2011)

Inclusion Body Expression and Refolding of Recombinant Bone Morphogenetic Protein-2
por: Nasrabadi, Davood, et al.
Publicado: (2018)

Use of recombinant human bone morphogenetic protein-2 in spine surgery
por: Lykissas, Marios, et al.
Publicado: (2017)

Bone Morphogenetic Protein 2 Promotes Bone Formation in Bone Defects in Which Bone Remodeling Is Suppressed by Long-Term and High-Dose Zoledronic Acid
por: Moon, Young Jae, et al.
Publicado: (2023)

Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy
por: Porcelli, Letizia, et al.
Publicado: (2015)

Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer
por: Xing, Zhen, et al.
Publicado: (2015)

An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression
por: Ryu, Jaewook, et al.
Publicado: (2018)

Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A
por: Bao, Zhuo, et al.
Publicado: (2022)

The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells
por: Liu, Xumei, et al.
Publicado: (2022)

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
por: Cho, Hyun-Soo, et al.
Publicado: (2012)

Aurora kinase inhibitors: Progress towards the clinic
por: Kollareddy, Madhu, et al.
Publicado: (2012)

Aurora Kinase Inhibitors: Current Status and Outlook
por: Bavetsias, Vassilios, et al.
Publicado: (2015)

Functions of Aurora kinase C in meiosis and cancer
por: Quartuccio, Suzanne M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9pjik1gs19iken552qi393cpda