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Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells
Effective new therapies are urgently needed for the treatment of multiple myeloma (MM), an incurable hematological malignancy. In this study, we evaluated the effects of piperlongumine on MM cell proliferation both in vivo and in vitro. Piperlongumine inhibited the proliferation of MM cells by induc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341994/ https://www.ncbi.nlm.nih.gov/pubmed/27634873 http://dx.doi.org/10.18632/oncotarget.11988 |
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author | Yao, Yao Sun, Yueyue Shi, Min Xia, Dandan Zhao, Kai Zeng, Lingyu Yao, Ruosi Zhang, Ying Li, Zhenyu Niu, Mingshan Xu, Kailin |
author_facet | Yao, Yao Sun, Yueyue Shi, Min Xia, Dandan Zhao, Kai Zeng, Lingyu Yao, Ruosi Zhang, Ying Li, Zhenyu Niu, Mingshan Xu, Kailin |
author_sort | Yao, Yao |
collection | PubMed |
description | Effective new therapies are urgently needed for the treatment of multiple myeloma (MM), an incurable hematological malignancy. In this study, we evaluated the effects of piperlongumine on MM cell proliferation both in vivo and in vitro. Piperlongumine inhibited the proliferation of MM cells by inducing cell apoptosis and blocking osteoclastogenesis. Notably, piperlongumine also reduced bortezomib resistance in MM cells. In a disseminated MM mouse model, piperlongumine prolonged the survival of tumor-bearing mice without causing any obvious toxicity. Mechanistically, piperlongumine inhibited the STAT3 signal pathway in MM cells by binding directly to the STAT3 Cys712 residue. These findings suggest that the clinical use of piperlongumine to overcome bortezomib resistance in MM should be evaluated. |
format | Online Article Text |
id | pubmed-5341994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53419942017-03-27 Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells Yao, Yao Sun, Yueyue Shi, Min Xia, Dandan Zhao, Kai Zeng, Lingyu Yao, Ruosi Zhang, Ying Li, Zhenyu Niu, Mingshan Xu, Kailin Oncotarget Research Paper Effective new therapies are urgently needed for the treatment of multiple myeloma (MM), an incurable hematological malignancy. In this study, we evaluated the effects of piperlongumine on MM cell proliferation both in vivo and in vitro. Piperlongumine inhibited the proliferation of MM cells by inducing cell apoptosis and blocking osteoclastogenesis. Notably, piperlongumine also reduced bortezomib resistance in MM cells. In a disseminated MM mouse model, piperlongumine prolonged the survival of tumor-bearing mice without causing any obvious toxicity. Mechanistically, piperlongumine inhibited the STAT3 signal pathway in MM cells by binding directly to the STAT3 Cys712 residue. These findings suggest that the clinical use of piperlongumine to overcome bortezomib resistance in MM should be evaluated. Impact Journals LLC 2016-09-13 /pmc/articles/PMC5341994/ /pubmed/27634873 http://dx.doi.org/10.18632/oncotarget.11988 Text en Copyright: © 2016 Yao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yao, Yao Sun, Yueyue Shi, Min Xia, Dandan Zhao, Kai Zeng, Lingyu Yao, Ruosi Zhang, Ying Li, Zhenyu Niu, Mingshan Xu, Kailin Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title | Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title_full | Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title_fullStr | Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title_full_unstemmed | Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title_short | Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells |
title_sort | piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting stat3 in multiple myeloma cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341994/ https://www.ncbi.nlm.nih.gov/pubmed/27634873 http://dx.doi.org/10.18632/oncotarget.11988 |
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