CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma

Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation, which leads to deregulated expression of the cell cycle regulatory protein cyclin D1 (CCND1). Genomic studies of MCL have also identified recurrent mutations in the coding region of CCND1. However, the functional consequence...

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Detalles Bibliográficos
Autores principales: Mohanty, Atish, Sandoval, Natalie, Das, Manasi, Pillai, Raju, Chen, Lu, Chen, Robert W., Amin, Hesham M., Wang, Michael, Marcucci, Guido, Weisenburger, Dennis D., Rosen, Steven T., Pham, Lan V., Ngo, Vu N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341999/
https://www.ncbi.nlm.nih.gov/pubmed/27713153
http://dx.doi.org/10.18632/oncotarget.12434

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