Engineering of double recombinant vaccinia virus with enhanced oncolytic potential for solid tumor virotherapy

Vaccinia virus (VACV) oncolytic therapy has been successful in a number of tumor models. In this study our goal was to generate a double recombinant vaccinia virus (VV-GMCSF-Lact) with enhanced antitumor activity that expresses exogenous proteins: the antitumor protein lactaptin and human granulocyt...

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Detalles Bibliográficos
Autores principales: Kochneva, Galina, Sivolobova, Galina, Tkacheva, Anastasiya, Grazhdantseva, Antonina, Troitskaya, Olga, Nushtaeva, Anna, Tkachenko, Anastasiya, Kuligina, Elena, Richter, Vladimir, Koval, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342044/
https://www.ncbi.nlm.nih.gov/pubmed/27708236
http://dx.doi.org/10.18632/oncotarget.12367

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