Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells “in vitro” and correlating with progression “in vivo”

The expression of Prostate Specific-Membrane Antigen (PSMA) increases in high-grade prostate carcinoma envisaging a role in growth and progression. We show here that clustering PSMA at LNCaP or PC3-PSMA cell membrane activates AKT and MAPK pathways thus promoting proliferation and survival. PSMA act...

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Detalles Bibliográficos
Autores principales: Perico, Maria Elisa, Grasso, Silvia, Brunelli, Matteo, Martignoni, Guido, Munari, Enrico, Moiso, Enrico, Fracasso, Giulio, Cestari, Tiziana, Naim, Hassan Y., Bronte, Vincenzo, Colombatti, Marco, Ramarli, Dunia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342045/
https://www.ncbi.nlm.nih.gov/pubmed/27713116
http://dx.doi.org/10.18632/oncotarget.12404

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