ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system

The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulat...

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Detalles Bibliográficos
Autores principales: Zuo, Chaohui, Sheng, Xinyi, Ma, Min, Xia, Man, Ouyang, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342061/
https://www.ncbi.nlm.nih.gov/pubmed/27626310
http://dx.doi.org/10.18632/oncotarget.11911
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author Zuo, Chaohui
Sheng, Xinyi
Ma, Min
Xia, Man
Ouyang, Linda
author_facet Zuo, Chaohui
Sheng, Xinyi
Ma, Min
Xia, Man
Ouyang, Linda
author_sort Zuo, Chaohui
collection PubMed
description The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. The expression of ISG15 and ISG15-mediated conjugation has been implicated in a wide range of human tumors and cancer cell lines, but the roles of ISG15 in tumorigenesis and responses to anticancer treatments remain largely unknown. In this review, we discuss the findings of recent studies with regard to the role of ISG15 pathways in cancers of the digestive system.
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spelling pubmed-53420612017-03-27 ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system Zuo, Chaohui Sheng, Xinyi Ma, Min Xia, Man Ouyang, Linda Oncotarget Review The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. The expression of ISG15 and ISG15-mediated conjugation has been implicated in a wide range of human tumors and cancer cell lines, but the roles of ISG15 in tumorigenesis and responses to anticancer treatments remain largely unknown. In this review, we discuss the findings of recent studies with regard to the role of ISG15 pathways in cancers of the digestive system. Impact Journals LLC 2016-09-08 /pmc/articles/PMC5342061/ /pubmed/27626310 http://dx.doi.org/10.18632/oncotarget.11911 Text en Copyright: © 2016 Zuo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Zuo, Chaohui
Sheng, Xinyi
Ma, Min
Xia, Man
Ouyang, Linda
ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title_full ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title_fullStr ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title_full_unstemmed ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title_short ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system
title_sort isg15 in the tumorigenesis and treatment of cancer: an emerging role in malignancies of the digestive system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342061/
https://www.ncbi.nlm.nih.gov/pubmed/27626310
http://dx.doi.org/10.18632/oncotarget.11911
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