Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

Recurrence of breast cancer disease years after treatment appears to arise from disseminated dormant tumor cells (DTC). The mechanisms underlying the outgrowth of DTC remain largely unknown. Here we demonstrate that dormant MCF-7 cells expressing LOXL2 acquire a cancer stem cell (CSC)-like phenotype...

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Detalles Bibliográficos
Autores principales: Weidenfeld, Keren, Schif-Zuck, Sagi, Abu-Tayeh, Hanan, Kang, Keunsoo, Kessler, Ofra, Weissmann, Marina, Neufeld, Gera, Barkan, Dalit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342084/
https://www.ncbi.nlm.nih.gov/pubmed/27655685
http://dx.doi.org/10.18632/oncotarget.12109

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