The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b

Mutations in the nucleophosmin 1 (NPM1) gene are the most frequent genetic alteration in acute myeloid leukemia (AML). Here, we showed that enforced expression of NPM1 mutation type A (NPM1-mA) inhibits myeloid differentiation of leukemia cells, whereas knockdown of NPM1-mA has the opposite effect....

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Detalles Bibliográficos
Autores principales: Zou, Qin, Tan, Shi, Yang, Zailin, Wang, Juan, Xian, Jingrong, Zhang, Shuaishuai, Jin, Hongjun, Yang, Liyuan, Wang, Lu, Zhang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342094/
https://www.ncbi.nlm.nih.gov/pubmed/27669739
http://dx.doi.org/10.18632/oncotarget.12216

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