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Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy

Patient-derived xenograft (PDX) mouse models of cancer are emerging as an important component of personalized precision cancer therapy. However, most models currently offered to patients have their tumors subcutaneously-transplanted in immunodeficient mice, which rarely metastasize. In contrast, ort...

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Detalles Bibliográficos
Autores principales:	Hiroshima, Yukihiko, Maawy, Ali, Zhang, Yong, Zhang, Nan, Murakami, Takashi, Chishima, Takashi, Tanaka, Kuniya, Ichikawa, Yasushi, Bouvet, Michael, Endo, Itaru, Hoffman, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342112/ https://www.ncbi.nlm.nih.gov/pubmed/27765934 http://dx.doi.org/10.18632/oncotarget.12322

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