Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid's anti-metastatic effect in 4T1 tumor bearing mice

Hypoxic in the tumor mass is leading to the myeloproliferative-like disease (leukemoid reaction) and anemia of body, which characterized by strong extensive extramedullary hematopoiesis (EMH) in spleen. As the key transcription factor of hypoxia, hypoxia-inducible factor-1 (HIF-1) activates the expr...

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Detalles Bibliográficos
Autores principales: Gao, Jian-Li, Shui, Yan-Mei, Jiang, Wei, Huang, En-Yi, Shou, Qi-Yang, Ji, Xin, He, Bai-Cheng, Lv, Gui-Yuan, He, Tong-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342124/
https://www.ncbi.nlm.nih.gov/pubmed/27708244
http://dx.doi.org/10.18632/oncotarget.12375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342124/
https://www.ncbi.nlm.nih.gov/pubmed/27708244
http://dx.doi.org/10.18632/oncotarget.12375

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