Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63

Recently, we have described that siRNA-mediated silencing of runt-related transcription factor 2 (RUNX2) improves anti-cancer drug gemcitabine (GEM) sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the augmentation of p53 family TAp63-dependent cell death pathway. In this ma...

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Detalles Bibliográficos
Autores principales: Ozaki, Toshinori, Nakamura, Mizuyo, Ogata, Takehiro, Sang, Meijie, Yoda, Hiroyuki, Hiraoka, Kiriko, Sang, Meixiang, Shimozato, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342134/
https://www.ncbi.nlm.nih.gov/pubmed/27713122
http://dx.doi.org/10.18632/oncotarget.12433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342134/
https://www.ncbi.nlm.nih.gov/pubmed/27713122
http://dx.doi.org/10.18632/oncotarget.12433

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