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miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1
The human cervical cancer (CC) acts as the most common one of women tumors. However, the pathological changes and molecular alterations of CC are not clear. It has been reported that miR-202 takes part in the development and progression of different tumors. The present study aims to detect the expre...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342145/ https://www.ncbi.nlm.nih.gov/pubmed/27732565 http://dx.doi.org/10.18632/oncotarget.12499 |
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author | Yi, Yuexiong Li, Huirong Lv, Qiongying Wu, Kejia Zhang, Wenfen Zhang, Juan Zhu, Dingjun Liu, Qing Zhang, Wei |
author_facet | Yi, Yuexiong Li, Huirong Lv, Qiongying Wu, Kejia Zhang, Wenfen Zhang, Juan Zhu, Dingjun Liu, Qing Zhang, Wei |
author_sort | Yi, Yuexiong |
collection | PubMed |
description | The human cervical cancer (CC) acts as the most common one of women tumors. However, the pathological changes and molecular alterations of CC are not clear. It has been reported that miR-202 takes part in the development and progression of different tumors. The present study aims to detect the expression of miR-202 in 100 cases of CC tissues and cells, and then we continued to investigate the potential mechanisms of miR-202 in CC cells. In this work, we found that the expression of miR-202 is obviously decreased in both CC cell lines and tissues, and negatively related with the expression of cyclin D1 in SiHa, HeLa and Caski cells. In-vitro assay revealed that the ectopic expression of miR-202 suppressed the proliferation, migration and invasion of SiHa and HeLa cells. Additionally, the over-expression of miR-202 extremely affected the expression of cyclin D1 protein. Notably, the over-expression of cyclin D1 in SiHa and HeLa cells with miR-202 mimics attenuated the inhibitory effects of miR-202 on cell proliferation, migration and invasion. In conclusion, our study identified that miR-202 plays an important role in regulating cell proliferation, migration and invasion of CC by directly targeting cyclin D1, thus miR-202 may represent a potential therapeutic target for patients with cervical cancer. |
format | Online Article Text |
id | pubmed-5342145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53421452017-03-24 miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 Yi, Yuexiong Li, Huirong Lv, Qiongying Wu, Kejia Zhang, Wenfen Zhang, Juan Zhu, Dingjun Liu, Qing Zhang, Wei Oncotarget Research Paper The human cervical cancer (CC) acts as the most common one of women tumors. However, the pathological changes and molecular alterations of CC are not clear. It has been reported that miR-202 takes part in the development and progression of different tumors. The present study aims to detect the expression of miR-202 in 100 cases of CC tissues and cells, and then we continued to investigate the potential mechanisms of miR-202 in CC cells. In this work, we found that the expression of miR-202 is obviously decreased in both CC cell lines and tissues, and negatively related with the expression of cyclin D1 in SiHa, HeLa and Caski cells. In-vitro assay revealed that the ectopic expression of miR-202 suppressed the proliferation, migration and invasion of SiHa and HeLa cells. Additionally, the over-expression of miR-202 extremely affected the expression of cyclin D1 protein. Notably, the over-expression of cyclin D1 in SiHa and HeLa cells with miR-202 mimics attenuated the inhibitory effects of miR-202 on cell proliferation, migration and invasion. In conclusion, our study identified that miR-202 plays an important role in regulating cell proliferation, migration and invasion of CC by directly targeting cyclin D1, thus miR-202 may represent a potential therapeutic target for patients with cervical cancer. Impact Journals LLC 2016-10-06 /pmc/articles/PMC5342145/ /pubmed/27732565 http://dx.doi.org/10.18632/oncotarget.12499 Text en Copyright: © 2016 Yi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yi, Yuexiong Li, Huirong Lv, Qiongying Wu, Kejia Zhang, Wenfen Zhang, Juan Zhu, Dingjun Liu, Qing Zhang, Wei miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title | miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title_full | miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title_fullStr | miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title_full_unstemmed | miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title_short | miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1 |
title_sort | mir-202 inhibits the progression of human cervical cancer through inhibition of cyclin d1 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342145/ https://www.ncbi.nlm.nih.gov/pubmed/27732565 http://dx.doi.org/10.18632/oncotarget.12499 |
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