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Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation
The FoxA family of pioneer transcription factors regulates hepatitis B virus (HBV) transcription, and hence viral replication. Hepatocyte-specific FoxA-deficiency in the HBV transgenic mouse model of chronic infection prevents the transcription of the viral DNA genome as a result of the failure of t...
Autores principales: | McFadden, Vanessa C., Shalaby, Rasha E., Iram, Saira, Oropeza, Claudia E., Landolfi, Jennifer A., Lyubimov, Alexander V., Maienschein-Cline, Mark, Green, Stefan J., Kaestner, Klaus H., McLachlan, Alan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342274/ https://www.ncbi.nlm.nih.gov/pubmed/28235042 http://dx.doi.org/10.1371/journal.ppat.1006239 |
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