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Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis
Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are r...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342352/ https://www.ncbi.nlm.nih.gov/pubmed/27384673 http://dx.doi.org/10.18632/oncotarget.10074 |
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author | Dalloneau, Emilie Baroukh, Nadine Mavridis, Konstantinos Maillet, Agnès Gueugnon, Fabien Courty, Yves Petit, Agnès Kryza, Thomas Del Rio, Maguy Guyetant, Serge Castaneda, Diana Carolina Cadena Dhommée, Christine Arnoult, Christophe Scorilas, Andreas Gouilleux-Gruart, Valérie Heuzé-Vourc'h, Nathalie |
author_facet | Dalloneau, Emilie Baroukh, Nadine Mavridis, Konstantinos Maillet, Agnès Gueugnon, Fabien Courty, Yves Petit, Agnès Kryza, Thomas Del Rio, Maguy Guyetant, Serge Castaneda, Diana Carolina Cadena Dhommée, Christine Arnoult, Christophe Scorilas, Andreas Gouilleux-Gruart, Valérie Heuzé-Vourc'h, Nathalie |
author_sort | Dalloneau, Emilie |
collection | PubMed |
description | Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients. Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that FCGRT mRNA down-regulation is a robust and independent, unfavorable predictive factor of NSCLC patient survival. We conclude that FCGRT mRNA expression may be a useful additional marker for immunoscoring, reflecting tumor immune system, and help in the decision-making process for NSCLC patients. |
format | Online Article Text |
id | pubmed-5342352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53423522017-03-22 Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis Dalloneau, Emilie Baroukh, Nadine Mavridis, Konstantinos Maillet, Agnès Gueugnon, Fabien Courty, Yves Petit, Agnès Kryza, Thomas Del Rio, Maguy Guyetant, Serge Castaneda, Diana Carolina Cadena Dhommée, Christine Arnoult, Christophe Scorilas, Andreas Gouilleux-Gruart, Valérie Heuzé-Vourc'h, Nathalie Oncotarget Research Paper Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients. Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that FCGRT mRNA down-regulation is a robust and independent, unfavorable predictive factor of NSCLC patient survival. We conclude that FCGRT mRNA expression may be a useful additional marker for immunoscoring, reflecting tumor immune system, and help in the decision-making process for NSCLC patients. Impact Journals LLC 2016-06-15 /pmc/articles/PMC5342352/ /pubmed/27384673 http://dx.doi.org/10.18632/oncotarget.10074 Text en Copyright: © 2016 Dalloneau et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Dalloneau, Emilie Baroukh, Nadine Mavridis, Konstantinos Maillet, Agnès Gueugnon, Fabien Courty, Yves Petit, Agnès Kryza, Thomas Del Rio, Maguy Guyetant, Serge Castaneda, Diana Carolina Cadena Dhommée, Christine Arnoult, Christophe Scorilas, Andreas Gouilleux-Gruart, Valérie Heuzé-Vourc'h, Nathalie Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title | Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title_full | Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title_fullStr | Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title_full_unstemmed | Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title_short | Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
title_sort | downregulation of the neonatal fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342352/ https://www.ncbi.nlm.nih.gov/pubmed/27384673 http://dx.doi.org/10.18632/oncotarget.10074 |
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