Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

BACKGROUND: Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells. RESULTS: Low PDH levels...

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Detalles Bibliográficos
Autores principales: Guimarães, Talita Antunes, Farias, Lucyana Conceição, Santos, Eliane Sobrinho, de Carvalho Fraga, Carlos Alberto, Orsini, Lissur Azevedo, de Freitas Teles, Leandro, Feltenberger, John David, de Jesus, Sabrina Ferreira, de Souza, Marcela Gonçalves, Sousa Santos, Sérgio Henrique, de Paula, Alfredo Maurício Batista, Gomez, Ricardo Santiago, Guimarães, André Luiz Sena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342401/
https://www.ncbi.nlm.nih.gov/pubmed/27474170
http://dx.doi.org/10.18632/oncotarget.10842

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