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Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth

Osteopontin (OPN), a phosphorylated glycoprotein, is frequently overexpressed in cancer. Among the three OPN isoforms, OPN-a is the most highly expressed in lung cancer cell lines and lung tumors. Overexpression of OPN-a greatly reduced CL1-5 lung adenocarcinoma cell growth, but had no effect on gro...

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Detalles Bibliográficos
Autores principales:	Sun, Shih-Jung, Wu, Chun-Chi, Sheu, Gwo-Tarng, Chang, Hui-Yi, Chen, Mei-Yu, Lin, Yu-Ying, Chuang, Cheng-Yen, Hsu, Shih-Lan, Chang, Jinghua Tsai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342437/ https://www.ncbi.nlm.nih.gov/pubmed/27487131 http://dx.doi.org/10.18632/oncotarget.10865

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