Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

Internal tandem duplications of the juxtamembrane domain of FLT3 (FLT3/ITD) are among the most common mutations in Acute Myeloid Leukemia (AML). Resulting in constitutive activation of the kinase, FLT3/ITD portends a particularly poor prognosis, with reduced overall survival and increased rates of r...

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Detalles Bibliográficos
Autores principales: Poitras, Jennifer L., Heiser, Diane, Li, Li, Nguyen, Bao, Nagai, Kozo, Duffield, Amy S., Gamper, Christopher, Small, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342464/
https://www.ncbi.nlm.nih.gov/pubmed/27636998
http://dx.doi.org/10.18632/oncotarget.11986

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