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Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial

Suboptimal vitamin D status is common among humans, and might increase bone resorption with subsequent negative effects on bone health. Fatty fish, including Atlantic salmon, is an important dietary vitamin D source. However, due to a considerable change in fish feed composition, the contribution of...

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Autores principales: Graff, Ingvild Eide, Øyen, Jannike, Kjellevold, Marian, Frøyland, Livar, Gjesdal, Clara Gram, Almås, Bjørg, Rosenlund, Grethe, Lie, Øyvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342470/
https://www.ncbi.nlm.nih.gov/pubmed/27542236
http://dx.doi.org/10.18632/oncotarget.10171
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author Graff, Ingvild Eide
Øyen, Jannike
Kjellevold, Marian
Frøyland, Livar
Gjesdal, Clara Gram
Almås, Bjørg
Rosenlund, Grethe
Lie, Øyvind
author_facet Graff, Ingvild Eide
Øyen, Jannike
Kjellevold, Marian
Frøyland, Livar
Gjesdal, Clara Gram
Almås, Bjørg
Rosenlund, Grethe
Lie, Øyvind
author_sort Graff, Ingvild Eide
collection PubMed
description Suboptimal vitamin D status is common among humans, and might increase bone resorption with subsequent negative effects on bone health. Fatty fish, including Atlantic salmon, is an important dietary vitamin D source. However, due to a considerable change in fish feed composition, the contribution of vitamin D from salmon fillet has been reduced. The main objective was to investigate if intake of vitamin D(3) enriched salmon or vitamin D(3) tablets decreased bone biomarkers (urinary N-telopeptides, deoxypyridinoline, serum bone-specific alkaline phosphatase, and osteocalcin) compared to a low vitamin D(3) intake. The 122 healthy postmenopausal women included in this 12 weeks intervention trial were randomized into four groups: three salmon groups (150 grams/two times/week) and one tablet group (800 IU vitamin D and 1000 mg calcium/day). The salmon groups also received calcium supplements. The salmon had three different vitamin D(3)/vitamin K(1) combinations: high D(3)+high K(1), low D(3)+high K(1), or high D(3)+low K(1). Increased intake of salmon containing high levels of vitamin D(3) (0.35-0.38 mg/kg/fillet) and supplements with the same weekly contribution had a positive influence on bone health as measured by bone biomarkers in postmenopausal women. Consequently, an increased level of vitamin D(3) at least to original level in feed for salmonids will contribute to an improved vitamin D(3) status and may improve human bone health.
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spelling pubmed-53424702017-03-24 Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial Graff, Ingvild Eide Øyen, Jannike Kjellevold, Marian Frøyland, Livar Gjesdal, Clara Gram Almås, Bjørg Rosenlund, Grethe Lie, Øyvind Oncotarget Research Paper: Gerotarget (Focus on Aging) Suboptimal vitamin D status is common among humans, and might increase bone resorption with subsequent negative effects on bone health. Fatty fish, including Atlantic salmon, is an important dietary vitamin D source. However, due to a considerable change in fish feed composition, the contribution of vitamin D from salmon fillet has been reduced. The main objective was to investigate if intake of vitamin D(3) enriched salmon or vitamin D(3) tablets decreased bone biomarkers (urinary N-telopeptides, deoxypyridinoline, serum bone-specific alkaline phosphatase, and osteocalcin) compared to a low vitamin D(3) intake. The 122 healthy postmenopausal women included in this 12 weeks intervention trial were randomized into four groups: three salmon groups (150 grams/two times/week) and one tablet group (800 IU vitamin D and 1000 mg calcium/day). The salmon groups also received calcium supplements. The salmon had three different vitamin D(3)/vitamin K(1) combinations: high D(3)+high K(1), low D(3)+high K(1), or high D(3)+low K(1). Increased intake of salmon containing high levels of vitamin D(3) (0.35-0.38 mg/kg/fillet) and supplements with the same weekly contribution had a positive influence on bone health as measured by bone biomarkers in postmenopausal women. Consequently, an increased level of vitamin D(3) at least to original level in feed for salmonids will contribute to an improved vitamin D(3) status and may improve human bone health. Impact Journals LLC 2016-08-14 /pmc/articles/PMC5342470/ /pubmed/27542236 http://dx.doi.org/10.18632/oncotarget.10171 Text en Copyright: © 2016 Graff et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Gerotarget (Focus on Aging)
Graff, Ingvild Eide
Øyen, Jannike
Kjellevold, Marian
Frøyland, Livar
Gjesdal, Clara Gram
Almås, Bjørg
Rosenlund, Grethe
Lie, Øyvind
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title_full Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title_fullStr Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title_full_unstemmed Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title_short Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: a randomized intervention trial
title_sort reduced bone resorption by intake of dietary vitamin d and k from tailor-made atlantic salmon: a randomized intervention trial
topic Research Paper: Gerotarget (Focus on Aging)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342470/
https://www.ncbi.nlm.nih.gov/pubmed/27542236
http://dx.doi.org/10.18632/oncotarget.10171
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