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SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms are not fully understood, and effective therapies are lacking. We investigated the expression of the mitochondrial deacetylase sirtuin 3 (SIRT3...

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Detalles Bibliográficos
Autores principales:	Akamata, Kaname, Wei, Jun, Bhattacharyya, Mitra, Cheresh, Paul, Bonner, Michael Y., Arbiser, Jack L., Raparia, Kirtee, Gupta, Mahesh P., Kamp, David W., Varga, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342480/ https://www.ncbi.nlm.nih.gov/pubmed/27732568 http://dx.doi.org/10.18632/oncotarget.12504

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