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Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis
BACKGROUND: Accumulated studies have exploited the association between osteopontin (OPN) expression and survival of patients with gastric cancer (GC), however, the results were controversial. Thus, we performed a meta-analysis, aiming to investigate the prognostic role of OPN for GC patients and to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342506/ https://www.ncbi.nlm.nih.gov/pubmed/27626167 http://dx.doi.org/10.18632/oncotarget.11936 |
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author | Gu, Xiaobin Gao, Xian-Shu Ma, Mingwei Qin, Shangbin Qi, Xin Li, Xiaoying Sun, Shaoqian Yu, Hao Wang, Wen Zhou, Dong |
author_facet | Gu, Xiaobin Gao, Xian-Shu Ma, Mingwei Qin, Shangbin Qi, Xin Li, Xiaoying Sun, Shaoqian Yu, Hao Wang, Wen Zhou, Dong |
author_sort | Gu, Xiaobin |
collection | PubMed |
description | BACKGROUND: Accumulated studies have exploited the association between osteopontin (OPN) expression and survival of patients with gastric cancer (GC), however, the results were controversial. Thus, we performed a meta-analysis, aiming to investigate the prognostic role of OPN for GC patients and to explore the association between OPN and clinicalpathological features of GC. RESULTS: A total of ten studies involving 1775 patients were included in final meta-analysis. Of the included studies, nine were conducted on Asian patients and one was performed on Caucasian patients. Regarding OPN detection, immunohistochemistry (IHC) was used on tissue specimens in eight studies and enzyme linked immunosorbent assay (ELISA) was used on plasma specimens in two studies. The pooled data showed that high OPN expression was correlated with poor OS (HR = 1.59, 95% CI: 1.15–2.22, p = 0.006). Subgroup analyses demonstrated that OPN had enhanced prognostic value for Asian patients (HR = 1.64, 95% CI = 1.11–2.41, p = 0.012) and for patients receiving surgical resection (HR = 1.6, 95% CI = 1.04–2.48, p = 0.034). In addition, the results also showed that elevated OPN expression was associated with lymph node metastasis, TNM stage, depth of invasion, tumor size and distant metastasis in GC. METHODS: Relevant studies were retrieved through PubMed, Embase and Web of Science. Combined hazard ratio (HR) and 95% confidence interval (CI) were calculated to assess the association between OPN and overall survival (OS). Subgroup analyses and publication bias were also conducted. CONCLUSIONS: OPN overexpression was correlated with poor OS and clinical features reflecting high aggressiveness in patients with GC. OPN was a promising prognostic biomarker for GC. |
format | Online Article Text |
id | pubmed-5342506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53425062017-03-24 Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis Gu, Xiaobin Gao, Xian-Shu Ma, Mingwei Qin, Shangbin Qi, Xin Li, Xiaoying Sun, Shaoqian Yu, Hao Wang, Wen Zhou, Dong Oncotarget Research Paper BACKGROUND: Accumulated studies have exploited the association between osteopontin (OPN) expression and survival of patients with gastric cancer (GC), however, the results were controversial. Thus, we performed a meta-analysis, aiming to investigate the prognostic role of OPN for GC patients and to explore the association between OPN and clinicalpathological features of GC. RESULTS: A total of ten studies involving 1775 patients were included in final meta-analysis. Of the included studies, nine were conducted on Asian patients and one was performed on Caucasian patients. Regarding OPN detection, immunohistochemistry (IHC) was used on tissue specimens in eight studies and enzyme linked immunosorbent assay (ELISA) was used on plasma specimens in two studies. The pooled data showed that high OPN expression was correlated with poor OS (HR = 1.59, 95% CI: 1.15–2.22, p = 0.006). Subgroup analyses demonstrated that OPN had enhanced prognostic value for Asian patients (HR = 1.64, 95% CI = 1.11–2.41, p = 0.012) and for patients receiving surgical resection (HR = 1.6, 95% CI = 1.04–2.48, p = 0.034). In addition, the results also showed that elevated OPN expression was associated with lymph node metastasis, TNM stage, depth of invasion, tumor size and distant metastasis in GC. METHODS: Relevant studies were retrieved through PubMed, Embase and Web of Science. Combined hazard ratio (HR) and 95% confidence interval (CI) were calculated to assess the association between OPN and overall survival (OS). Subgroup analyses and publication bias were also conducted. CONCLUSIONS: OPN overexpression was correlated with poor OS and clinical features reflecting high aggressiveness in patients with GC. OPN was a promising prognostic biomarker for GC. Impact Journals LLC 2016-09-10 /pmc/articles/PMC5342506/ /pubmed/27626167 http://dx.doi.org/10.18632/oncotarget.11936 Text en Copyright: © 2016 Gu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Gu, Xiaobin Gao, Xian-Shu Ma, Mingwei Qin, Shangbin Qi, Xin Li, Xiaoying Sun, Shaoqian Yu, Hao Wang, Wen Zhou, Dong Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title | Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title_full | Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title_fullStr | Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title_full_unstemmed | Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title_short | Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
title_sort | prognostic significance of osteopontin expression in gastric cancer: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342506/ https://www.ncbi.nlm.nih.gov/pubmed/27626167 http://dx.doi.org/10.18632/oncotarget.11936 |
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