A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration

Myeloma (MM) cells and osteoclasts are mutually interacted to enhance MM growth while creating acidic bone lesions. Here, we explored acid sensing of MM cells and its role in MM cell response to acidic conditions. Acidic conditions activated the PI3K-Akt signaling in MM cells while upregulating the...

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Detalles Bibliográficos
Autores principales: Amachi, Ryota, Hiasa, Masahiro, Teramachi, Jumpei, Harada, Takeshi, Oda, Asuka, Nakamura, Shingen, Hanson, Derek, Watanabe, Keiichiro, Fujii, Shiro, Miki, Hirokazu, Kagawa, Kumiko, Iwasa, Masami, Endo, Itsuro, Kondo, Takeshi, Yoshida, Sumiko, Aihara, Ken-Ichi, Kurahashi, Kiyoe, Kuroda, Yoshiaki, Horikawa, Hideaki, Tanaka, Eiji, Matsumoto, Toshio, Abe, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342564/
https://www.ncbi.nlm.nih.gov/pubmed/27626482
http://dx.doi.org/10.18632/oncotarget.11927

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