Cargando…
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population
RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. Al...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342566/ https://www.ncbi.nlm.nih.gov/pubmed/27765928 http://dx.doi.org/10.18632/oncotarget.12297 |
_version_ | 1782513210150092800 |
---|---|
author | Yan, Shouchun Xia, Ridong Jin, Tianbo Ren, Hui Yang, Hua Li, Jing Yan, Mengdan Zhu, Yuanyuan Chen, Mingwei |
author_facet | Yan, Shouchun Xia, Ridong Jin, Tianbo Ren, Hui Yang, Hua Li, Jing Yan, Mengdan Zhu, Yuanyuan Chen, Mingwei |
author_sort | Yan, Shouchun |
collection | PubMed |
description | RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. All study samples (554 LC cases and 696 cancer-free controls) were collected from the Affiliated Hospital of Xizang Minzu University in China. We assessed associations between SNPs and LC risk using various several genetic models (codominant, dominant, recessive, overdominant, and additive). Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35–12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43–18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43–18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model). Haplotype analysis suggested that “CTC” was associated with a 0.8-fold decrease in LC risk (OR = 0.80, 95% CI, 0.63–1.00; Pearson's p = 0.05). These findings suggest a potential association between RTEL1 polymorphisms and LC risk in a Chinese Han population. |
format | Online Article Text |
id | pubmed-5342566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53425662017-03-24 RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population Yan, Shouchun Xia, Ridong Jin, Tianbo Ren, Hui Yang, Hua Li, Jing Yan, Mengdan Zhu, Yuanyuan Chen, Mingwei Oncotarget Research Paper RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. All study samples (554 LC cases and 696 cancer-free controls) were collected from the Affiliated Hospital of Xizang Minzu University in China. We assessed associations between SNPs and LC risk using various several genetic models (codominant, dominant, recessive, overdominant, and additive). Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35–12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43–18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43–18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model). Haplotype analysis suggested that “CTC” was associated with a 0.8-fold decrease in LC risk (OR = 0.80, 95% CI, 0.63–1.00; Pearson's p = 0.05). These findings suggest a potential association between RTEL1 polymorphisms and LC risk in a Chinese Han population. Impact Journals LLC 2016-09-28 /pmc/articles/PMC5342566/ /pubmed/27765928 http://dx.doi.org/10.18632/oncotarget.12297 Text en Copyright: © 2016 Yan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yan, Shouchun Xia, Ridong Jin, Tianbo Ren, Hui Yang, Hua Li, Jing Yan, Mengdan Zhu, Yuanyuan Chen, Mingwei RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title | RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title_full | RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title_fullStr | RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title_full_unstemmed | RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title_short | RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population |
title_sort | rtel1 polymorphisms are associated with lung cancer risk in the chinese han population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342566/ https://www.ncbi.nlm.nih.gov/pubmed/27765928 http://dx.doi.org/10.18632/oncotarget.12297 |
work_keys_str_mv | AT yanshouchun rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT xiaridong rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT jintianbo rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT renhui rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT yanghua rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT lijing rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT yanmengdan rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT zhuyuanyuan rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation AT chenmingwei rtel1polymorphismsareassociatedwithlungcancerriskinthechinesehanpopulation |