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Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia

OBJECTIVE: The aim of this study was to investigate the anti-leukemic activity of the Bruton tyrosine kinase inhibitor Ibrutinib in combination with the small molecule MDM-2 inhibitor Nutlin-3 in preclinical models. METHODS: The potential efficacy of the Ibrutinib/Nutlin-3 combination was evaluated...

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Detalles Bibliográficos
Autores principales:	Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Rigolin, Gian Matteo, Casciano, Fabio, Arcidiacono, Maria Vittoria, Celeghini, Claudio, Cuneo, Antonio, Zauli, Giorgio, Secchiero, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342579/ https://www.ncbi.nlm.nih.gov/pubmed/27661115 http://dx.doi.org/10.18632/oncotarget.12139

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