PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

Cancer cells are thought to use actin rich invadopodia to facilitate matrix degradation. Formation and maturation of invadopodia requires the co-ordained activity of Rho-GTPases, however the molecular mechanisms that underlie the invadopodia lifecycle are not fully elucidated. Previous work has sugg...

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Detalles Bibliográficos
Autores principales: Nicholas, Nicole S., Pipili, Aikaterini, Lesjak, Michaela S., Ameer, Simon M., Geh, Jenny L. C., Healy, Ciaran, Ross, Alistair D. MacKenzie, Parsons, Maddy, Nestle, Frank O., Lacy, Katie E., Wells, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342596/
https://www.ncbi.nlm.nih.gov/pubmed/27765920
http://dx.doi.org/10.18632/oncotarget.12282

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