Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salv...

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Detalles Bibliográficos
Autores principales: Wang, Liuyang, Ko, Emily R., Gilchrist, James J., Pittman, Kelly J., Rautanen, Anna, Pirinen, Matti, Thompson, J. Will, Dubois, Laura G., Langley, Raymond J., Jaslow, Sarah L., Salinas, Raul E., Rouse, D. Clayburn, Moseley, M. Arthur, Mwarumba, Salim, Njuguna, Patricia, Mturi, Neema, Williams, Thomas N., Scott, J. Anthony G., Hill, Adrian V. S., Woods, Christopher W., Ginsburg, Geoffrey S., Tsalik, Ephraim L., Ko, Dennis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342653/
https://www.ncbi.nlm.nih.gov/pubmed/28345042
http://dx.doi.org/10.1126/sciadv.1602096

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