BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), but also a potent inhibitor of the IKK-related kinase, TANKbinding kinase 1 (TBK1) and IKKɛ. In this study we attempted to elucidate the molecular mechanism(s) underlying the inhibition of BX-795 on Herpes simplex virus (HSV) re...

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Detalles Bibliográficos
Autores principales: Su, Ai-rong, Qiu, Min, Li, Yan-lei, Xu, Wen-tao, Song, Si-wei, Wang, Xiao-hui, Song, Hong-yong, Zheng, Nan, Wu, Zhi-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342671/
https://www.ncbi.nlm.nih.gov/pubmed/28112176
http://dx.doi.org/10.1038/aps.2016.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342671/
https://www.ncbi.nlm.nih.gov/pubmed/28112176
http://dx.doi.org/10.1038/aps.2016.160

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