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Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells

Inhibition of androgen receptor (AR) signalling represents the conventional medical management of prostate cancer. Ultimately this treatment fails because tumors develop an incurable, castrate resistant phenotype, resulting in an unmet need for new treatments in prostate cancer. The AR remains a via...

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Detalles Bibliográficos
Autores principales:	Logan, Ian R., McClurg, Urszula L., Jones, Dominic L., O'Neill, Daniel J., Shaheen, Fadhel S., Lunec, John, Gaughan, Luke, Robson, Craig N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342697/ https://www.ncbi.nlm.nih.gov/pubmed/27729622 http://dx.doi.org/10.18632/oncotarget.12542

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