Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib (BTZ) in leukemic cells in vitro. We here undertook a multi-modality (DNA, mRNA, miRNA) array-based analysis of human CCRF-CEM leukemia cells...

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Detalles Bibliográficos
Autores principales: Franke, Niels E., Kaspers, Gertjan L., Assaraf, Yehuda G., van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L., Poddighe, Pino J., Kole, Jeroen, Smeets, Serge J., Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M., Menezes, Rene X., Musters, Renée J.P., Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342701/
https://www.ncbi.nlm.nih.gov/pubmed/27542283
http://dx.doi.org/10.18632/oncotarget.11340

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