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SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

AKT1 is a cytosolic serine/threonine kinase that is overexpressed in various types of cancer and has a central role in human tumorigenesis. Although it is known that AKT1 is post-translationally modified in various ways including phosphorylation and ubiquitination, methylation has not been reported...

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Detalles Bibliográficos
Autores principales:	Yoshioka, Yuichiro, Suzuki, Takehiro, Matsuo, Yo, Nakakido, Makoto, Tsurita, Giichiro, Simone, Cristiano, Watanabe, Toshiaki, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342720/ https://www.ncbi.nlm.nih.gov/pubmed/27626683 http://dx.doi.org/10.18632/oncotarget.11898

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