Cargando…

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

Macrophages occur as resident cells of fetal origin or as infiltrating blood monocyte-derived cells. Despite the critical role of tumor-associated macrophages (TAMs) in tumor progression, the contribution of these developmentally and functionally distinct macrophage subsets and their alteration by t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Finkernagel, Florian, Reinartz, Silke, Lieber, Sonja, Adhikary, Till, Wortmann, Annika, Hoffmann, Nathalie, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Jansen, Julia M., Wagner, Uwe, Müller-Brüsselbach, Sabine, Müller, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342745/ https://www.ncbi.nlm.nih.gov/pubmed/27659538 http://dx.doi.org/10.18632/oncotarget.12180

Ejemplares similares

Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients
por: Adhikary, Till, et al.
Publicado: (2017)

The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state
por: Adhikary, Till, et al.
Publicado: (2015)

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites
por: Unger, Annika, et al.
Publicado: (2018)

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment
por: Schumann, Tim, et al.
Publicado: (2015)

A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome
por: Reinartz, Silke, et al.
Publicado: (2016)

The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis
por: Ojasalu, Kaire, et al.
Publicado: (2023)

The multicellular signalling network of ovarian cancer metastases
por: Sommerfeld, Leah, et al.
Publicado: (2021)

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures
por: Hammoud, Mohamad K., et al.
Publicado: (2022)

Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment
por: Sommerfeld, Leah, et al.
Publicado: (2022)

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment
por: Worzfeld, Thomas, et al.
Publicado: (2018)

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment
por: Reinartz, Silke, et al.
Publicado: (2018)

Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer
por: Dietze, Raimund, et al.
Publicado: (2021)

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse
por: Reinartz, Silke, et al.
Publicado: (2014)

Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion
por: Ojasalu, Kaire, et al.
Publicado: (2020)

Basal cell adhesion molecule promotes metastasis‐associated processes in ovarian cancer
por: Sivakumar, Suresh, et al.
Publicado: (2023)

Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling
por: Stockert, Josefine, et al.
Publicado: (2011)

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype
por: Rohnalter, Verena, et al.
Publicado: (2015)

Prognosis of ovarian cancer is associated with effector memory CD8(+) T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells
por: Lieber, Sonja, et al.
Publicado: (2018)

Genomewide Analyses Define Different Modes of Transcriptional Regulation by Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ)
por: Adhikary, Till, et al.
Publicado: (2011)

Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation
por: Vyas, Maulik, et al.
Publicado: (2017)

Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
por: Steitz, Anna Mary, et al.
Publicado: (2020)

MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6
por: Stielow, Bastian, et al.
Publicado: (2018)

The Unique Molecular and Cellular Microenvironment of Ovarian Cancer
por: Worzfeld, Thomas, et al.
Publicado: (2017)

Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion
por: Adhikary, T, et al.
Publicado: (2013)

Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
por: Koeniger, Anke, et al.
Publicado: (2021)

TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion
por: Steitz, Anna Mary, et al.
Publicado: (2023)

Zinc Finger Independent Genome-Wide Binding of Sp2 Potentiates Recruitment of Histone-Fold Protein Nf-y Distinguishing It from Sp1 and Sp3
por: Völkel, Sara, et al.
Publicado: (2015)

Tumor-suppressive disruption of cancer subtype-associated super enhancer circuits by small molecule treatment
por: Koeniger, Anke, et al.
Publicado: (2023)

Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
por: Finkernagel, Florian, et al.
Publicado: (2019)

Regulation of TAK1/TAB1-Mediated IL-1β Signaling by Cytoplasmic PPARβ/δ
por: Stockert, Josefine, et al.
Publicado: (2013)

Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma
por: Graumann, Johannes, et al.
Publicado: (2019)

Regulation of Cell Proliferation and Differentiation by PPARβ/δ
por: Müller, Rolf, et al.
Publicado: (2008)

Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1
por: Feld, Christine, et al.
Publicado: (2018)

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
por: Sachs, Parysatis, et al.
Publicado: (2019)

A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
por: Müller, Rolf, et al.
Publicado: (2008)

Nitrosative stress triggers microtubule reorganization in Arabidopsis thaliana
por: Lipka, Elisabeth, et al.
Publicado: (2014)

Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
por: Schuldner, Maximiliane, et al.
Publicado: (2019)

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex
por: Fritsch, Katharina, et al.
Publicado: (2016)

Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis
por: Sitaš, Barbara, et al.
Publicado: (2022)

Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor
por: Hannen, Ricarda, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6fdjfgjfk6o950dhr8mk6hh57f