TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

During apoptosis induction by TNF, the extrinsic and intrinsic apoptosis pathways converge at the lysosomal-mitochondrial interface. Earlier studies showed that the lysosomal aspartic protease Cathepsin D (CtsD) cleaves Bid to tBid, resulting in the amplification of the initial apoptotic cascade via...

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Detalles Bibliográficos
Autores principales: Fritsch, Jürgen, Fickers, Ricarda, Klawitter, Jan, Särchen, Vinzenz, Zingler, Philipp, Adam, Dieter, Janssen, Ottmar, Krause, Eberhard, Schütze, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342777/
https://www.ncbi.nlm.nih.gov/pubmed/27716614
http://dx.doi.org/10.18632/oncotarget.12411

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