Cargando…

Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth

Therapeutic strategies aiming at mobilizing immune effector cells to kill tumor cells independent of tumor mutational load and MHC expression status are expected to benefit cancer patients. Recently, we engineered various peptide-Fc fusion proteins for directing Fcg receptor-bearing immune cells tow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mobergslien, Anne, Peng, Qian, Vasovic, Vlada, Sioud, Mouldy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342789/ https://www.ncbi.nlm.nih.gov/pubmed/27713158 http://dx.doi.org/10.18632/oncotarget.12445

Ejemplares similares

Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells
por: Sioud, Mouldy, et al.
Publicado: (2015)

Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine
por: Sioud, Mouldy, et al.
Publicado: (2016)

Structural Requirements for the Binding of a Peptide to Prohibitins on the Cell Surface of Monocytes/Macrophages
por: Zhang, Qindong, et al.
Publicado: (2022)

Antibody Surface Profiling Identifies Glycoforms in Multiple Myeloma as Targets for Immunotherapy: From Antibody Derivatives to Mimetic Peptides for Killing Tumor Cells
por: Sioud, Mouldy, et al.
Publicado: (2023)

Precision Killing of M2 Macrophages with Phage-Displayed Peptide-Photosensitizer Conjugates
por: Sioud, Mouldy, et al.
Publicado: (2023)

Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
por: Sioud, Mouldy, et al.
Publicado: (2019)

Releasing the Immune System Brakes Using siRNAs Enhances Cancer Immunotherapy
por: Sioud, Mouldy
Publicado: (2019)

Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy
por: Sioud, Mouldy
Publicado: (2021)

RNA Interference
por: Sioud, Mouldy, et al.
Publicado: (2006)

Molecular Basis for the Immunostimulatory Potency of Small Interfering RNAs
por: Sioud, Mouldy, et al.
Publicado: (2006)

Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting
por: Zhang, Qindong, et al.
Publicado: (2023)

Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
por: Sioud, Mouldy, et al.
Publicado: (2021)

Design and production of a novel chimeric human growth hormone superagonist fused to human Fc domain
por: Mirbaha, Samira, et al.
Publicado: (2022)

Evidence for the involvement of G(i2) in activation of extracellular signal-regulated kinases in hepatocytes
por: Melien, Øyvind, et al.
Publicado: (2001)

Inhibition of Stromal PlGF Suppresses the Growth of Prostate Cancer Xenografts
por: Zins, Karin, et al.
Publicado: (2013)

Correction: Sioud et al. Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models. Cancers 2021, 13, 3356
por: Sioud, Mouldy, et al.
Publicado: (2021)

Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies
por: van der Horst, Hilma J., et al.
Publicado: (2020)

Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
por: Darvekar, Sagar, et al.
Publicado: (2020)

Soluble Expression of Fc-Fused T Cell Receptors Allows Yielding Novel Bispecific T Cell Engagers
por: Zhao, Wen-Bin, et al.
Publicado: (2021)

Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways
por: Zins, Karin, et al.
Publicado: (2016)

Expression of an immunocomplex consisting of Fc fragment fused with a consensus dengue envelope domain III in Saccharomyces cerevisiae
por: So, Kum-Kang, et al.
Publicado: (2021)

Vector induced skewing of antibody Fc-effector functions
por: Chung, A, et al.
Publicado: (2012)

Antigen-dependent modulation of immune responses to antigen-Fc fusion proteins by Fc-effector functions
por: Richel, Elie, et al.
Publicado: (2023)

Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis
por: Kasai, Tomonari, et al.
Publicado: (2012)

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
por: Mester, Simone, et al.
Publicado: (2021)

T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα
por: Shen, Yijun, et al.
Publicado: (2017)

Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc)
por: Aschmoneit, Nadine, et al.
Publicado: (2022)

Plant-derived PAP proteins fused to immunoglobulin A and M Fc domains induce anti-prostate cancer immune response in mice
por: Kang, Yang Joo, et al.
Publicado: (2023)

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site
por: Tolbert, William D., et al.
Publicado: (2020)

Polymeric human Fc-fusion proteins with modified effector functions
por: Mekhaiel, David N. A., et al.
Publicado: (2011)

IgG Fc engineering to modulate antibody effector functions
por: Wang, Xinhua, et al.
Publicado: (2017)

Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
por: Escobar-Cabrera, Eric, et al.
Publicado: (2017)

Engineered Fc-glycosylation switch to eliminate antibody effector function
por: Zhou, Qun, et al.
Publicado: (2020)

Fc-engineered antibodies with immune effector functions completely abolished
por: Wilkinson, Ian, et al.
Publicado: (2021)

Construction of Epstein-Bar virus cocktail peptide fused with Fcγ of IgG: as a potential delivery system for vaccine development
por: Amel Jamehdar, Saeid, et al.
Publicado: (2019)

Enhanced delivery of protein fused to cell penetrating peptides to mammalian cells
por: Moon, Jung-Il, et al.
Publicado: (2019)

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
por: Suzuki, Takuo, et al.
Publicado: (2021)

B Cell-Based Seamless Engineering of Antibody Fc Domains
por: Hashimoto, Koji, et al.
Publicado: (2016)

Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells from Patients with Crohn’s Disease
por: Espeland, Kristian, et al.
Publicado: (2023)

Binding of Tau-derived peptide-fused GFP to plant microtubules in Arabidopsis thaliana
por: Inaba, Hiroshi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5pgetq8skh6ila15gduj71ilek