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Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue

OBJECTIVES: To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients. METHODS: In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray...

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Autores principales: Ernst, Jutta, Ikenberg, Kristian, Apel, Barbara, Schumann, Desiree M., Huber, Gerhard, Studer, Gabriela, Rordorf, Tamara, Riesterer, Oliver, Rössle, Matthias, Korol, Dimitri, Bredell, Marius G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342803/
https://www.ncbi.nlm.nih.gov/pubmed/27764819
http://dx.doi.org/10.18632/oncotarget.12691
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author Ernst, Jutta
Ikenberg, Kristian
Apel, Barbara
Schumann, Desiree M.
Huber, Gerhard
Studer, Gabriela
Rordorf, Tamara
Riesterer, Oliver
Rössle, Matthias
Korol, Dimitri
Bredell, Marius G.
author_facet Ernst, Jutta
Ikenberg, Kristian
Apel, Barbara
Schumann, Desiree M.
Huber, Gerhard
Studer, Gabriela
Rordorf, Tamara
Riesterer, Oliver
Rössle, Matthias
Korol, Dimitri
Bredell, Marius G.
author_sort Ernst, Jutta
collection PubMed
description OBJECTIVES: To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients. METHODS: In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray (TMA). Where possible, samples were taken from central and peripheral regions of the tumor to generate a representative sample of the tumor. The expression level of CK19 was assessed by immunohistochemical staining. RESULTS: Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p<0.000) and disease specific survival (DSS; p=0.001). No significant difference could be shown for disease free survival (DFS) between patients with positive and negative CK19 staining (p=.094). CONCLUSION: This is the first description of the highly significant role of CK19 in a selective, organ specific head and neck cancer cohort. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer.
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spelling pubmed-53428032017-03-28 Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue Ernst, Jutta Ikenberg, Kristian Apel, Barbara Schumann, Desiree M. Huber, Gerhard Studer, Gabriela Rordorf, Tamara Riesterer, Oliver Rössle, Matthias Korol, Dimitri Bredell, Marius G. Oncotarget Research Paper OBJECTIVES: To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients. METHODS: In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray (TMA). Where possible, samples were taken from central and peripheral regions of the tumor to generate a representative sample of the tumor. The expression level of CK19 was assessed by immunohistochemical staining. RESULTS: Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p<0.000) and disease specific survival (DSS; p=0.001). No significant difference could be shown for disease free survival (DFS) between patients with positive and negative CK19 staining (p=.094). CONCLUSION: This is the first description of the highly significant role of CK19 in a selective, organ specific head and neck cancer cohort. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer. Impact Journals LLC 2016-10-15 /pmc/articles/PMC5342803/ /pubmed/27764819 http://dx.doi.org/10.18632/oncotarget.12691 Text en Copyright: © 2016 Ernst et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ernst, Jutta
Ikenberg, Kristian
Apel, Barbara
Schumann, Desiree M.
Huber, Gerhard
Studer, Gabriela
Rordorf, Tamara
Riesterer, Oliver
Rössle, Matthias
Korol, Dimitri
Bredell, Marius G.
Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title_full Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title_fullStr Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title_full_unstemmed Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title_short Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
title_sort expression of ck19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342803/
https://www.ncbi.nlm.nih.gov/pubmed/27764819
http://dx.doi.org/10.18632/oncotarget.12691
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