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Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation
Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL)....
Autores principales: | Bak, Sun-Uk, Kim, Suji, Hwang, Hae-Jun, Yun, Jung-A, Kim, Wan-Sung, Won, Moo-Ho, Kim, Ji-Yoon, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Young-Myeong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342874/ https://www.ncbi.nlm.nih.gov/pubmed/28088947 http://dx.doi.org/10.5483/BMBRep.2017.50.2.220 |
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