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Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw
OBJECTIVES: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is system...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Oral and Maxillofacial Surgeons
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342967/ https://www.ncbi.nlm.nih.gov/pubmed/28280705 http://dx.doi.org/10.5125/jkaoms.2017.43.1.16 |
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author | Kim, Yun-Ho Park, Han-Kyul Choi, Na-Rae Kim, Seong-Won Kim, Gyoo-Cheon Hwang, Dae-Seok Kim, Yong-Deok Shin, Sang-Hun Kim, Uk-Kyu |
author_facet | Kim, Yun-Ho Park, Han-Kyul Choi, Na-Rae Kim, Seong-Won Kim, Gyoo-Cheon Hwang, Dae-Seok Kim, Yong-Deok Shin, Sang-Hun Kim, Uk-Kyu |
author_sort | Kim, Yun-Ho |
collection | PubMed |
description | OBJECTIVES: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is systemic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ. MATERIALS AND METHODS: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to December 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient's medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level. RESULTS: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage. CONCLUSION: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment. |
format | Online Article Text |
id | pubmed-5342967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Association of Oral and Maxillofacial Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-53429672017-03-09 Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw Kim, Yun-Ho Park, Han-Kyul Choi, Na-Rae Kim, Seong-Won Kim, Gyoo-Cheon Hwang, Dae-Seok Kim, Yong-Deok Shin, Sang-Hun Kim, Uk-Kyu J Korean Assoc Oral Maxillofac Surg Original Article OBJECTIVES: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is systemic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ. MATERIALS AND METHODS: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to December 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient's medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level. RESULTS: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage. CONCLUSION: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment. The Korean Association of Oral and Maxillofacial Surgeons 2017-02 2017-02-20 /pmc/articles/PMC5342967/ /pubmed/28280705 http://dx.doi.org/10.5125/jkaoms.2017.43.1.16 Text en Copyright © 2017 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Yun-Ho Park, Han-Kyul Choi, Na-Rae Kim, Seong-Won Kim, Gyoo-Cheon Hwang, Dae-Seok Kim, Yong-Deok Shin, Sang-Hun Kim, Uk-Kyu Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title | Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title_full | Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title_fullStr | Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title_full_unstemmed | Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title_short | Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
title_sort | relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342967/ https://www.ncbi.nlm.nih.gov/pubmed/28280705 http://dx.doi.org/10.5125/jkaoms.2017.43.1.16 |
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